Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …

It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …

This article reports on the application of organically modified silica (ORMOSIL) nanoparticles
as a nonviral vector for efficient in vivo gene delivery. Highly monodispersed, stable …

The insulin-like growth factor 1 receptor (IGF-1R) plays crucial roles in developmental and
cancer biology. Most of its biological effects have been ascribed to its tyrosine kinase …

Emerging evidences suggest the existence of a new mode of epidermal growth factor
receptor (EGFR) signalling pathway in which activated EGFR undergoes nuclear …

Pancreatic cancer is characterised by desmoplasia, driven by activated pancreatic stellate
cells (PSC s). Over‐expression of FGF s and their receptors is a feature of pancreatic cancer …

Purpose: FGFR1 overexpression has been associated with endocrine resistance in ER+
breast cancer. We found FGFR1 localized in the nucleus of breast cancer cells in primary …

The cell membrane receptor ErbB-2 migrates to the nucleus. However, the mechanism of its
nuclear translocation is unclear. Here, we report a novel mechanism of its nuclear …

Expression of the type I transmembrane glycoprotein CD44 has recently been recognized as
a signature for cancer stem cells. In this study, we demonstrate that CD44, once engaged, is …

The incidence of neurological diseases of unknown etiology is increasing, including well-
studied diseases such as Alzhiemer's, Parkinson's, and multiple sclerosis. The blood-brain …