Manipulating microbiota in inflammatory bowel disease treatment: Clinical and natural product interventions explored

M Zhu, Y Song, Y Xu, H Xu - International journal of molecular sciences, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease,
that includes Crohn's disease (CD) and ulcerative colitis (UC), having progressively …

Systematic review: the association between the gut microbiota and medical therapies in inflammatory bowel disease

ST Radhakrishnan, JL Alexander… - Alimentary …, 2022 - Wiley Online Library
Background The gut microbiota has been implicated in the pathogenesis of inflammatory
bowel disease (IBD), with Faecalibacterium prausnitizii associated with protection, and …

Gut microbiome changes in patients with active left-sided ulcerative colitis after fecal microbiome transplantation and topical 5-aminosalicylic acid therapy

D Schierová, J Březina, J Mrázek, KO Fliegerová… - Cells, 2020 - mdpi.com
Ulcerative colitis (UC) is an inflammatory bowel disease, and intestinal bacteria are
implicated in the pathogenesis of this disorder. The administration of aminosalicylates (5 …

Current evidence and clinical relevance of drug-microbiota interactions in inflammatory bowel disease

HEF Becker, K Demers, LJJ Derijks… - Frontiers in …, 2023 - frontiersin.org
Background Inflammatory bowel disease (IBD) is a chronic relapsing-remitting disease. An
adverse immune reaction toward the intestinal microbiota is involved in the pathophysiology …

Fecal microbial transplantation versus mesalamine enema for treatment of active left-sided ulcerative colitis—Results of a randomized controlled trial

J Březina, L Bajer, P Wohl, D Ďuricová… - Journal of clinical …, 2021 - mdpi.com
Background and Aims: Ulcerative colitis (UC) is a chronic inflammatory disease. Fecal
microbial transplantation (FMT) is a promising alternative treatment. Methods: This …

Thiol–Disulfide Exchange Coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in Colitis

J Lu, T Shi, C Shi, F Chen, C Yang, X Xie, Z Wang… - Research, 2023 - spj.science.org
The cell-specific functions of nitric oxide (NO) in the intestinal microenvironment orchestrate
its therapeutic effects in ulcerative colitis. While most biomaterials show promise by eliciting …

[HTML][HTML] Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice

Z Yuan, L Yang, X Zhang, P Ji, Y Wei - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Abstract Huang-lian-Jie-du Decoction (HLJDD) is a classical prescription for clearing away
heat and detoxification. In order to screen the effective fraction of HLJDD in the treatment of …

The communication between intestinal microbiota and ulcerative colitis: an exploration of pathogenesis, animal models, and potential therapeutic strategies

Y Hu, Z Ye, M Wu, Y She, L Li, Y Xu, K Qin, Z Hu… - Frontiers in …, 2021 - frontiersin.org
Ulcerative Colitis (UC) is a chronic inflammatory bowel disease. The prolonged course of
UC and the lack of effective treatment management make it difficult to cure, affecting the …

A review of the biological and pharmacological activities of mesalazine or 5-aminosalicylic acid(5-ASA): an anti-ulcer and anti-oxidant drug

M Beiranvand - Inflammopharmacology, 2021 - Springer
Mesalazine, also known as 5-aminosalicylic acid (5-ASA), is a synthetic drug from the family
of nonsteroidal anti-inflammatory drugs (NSAIDs) used for inflammatory diseases of the …

The polyphosphate kinase of Escherichia coli is required for full production of the genotoxin colibactin

M Tang-Fichaux, CV Chagneau, N Bossuet-Greif… - Msphere, 2020 - Am Soc Microbiol
Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of
Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants …