Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

The generation of new lymphatic vessels through lymphangiogenesis and the remodelling
of existing lymphatics are thought to be important steps in cancer metastasis. The past …

The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their
possible involvement in neuropathological processes, yet little is known about their …

PIEZO1 is a cation channel that is activated by mechanical forces such as fluid shear stress
or membrane stretch. PIEZO1 loss-of-function mutations in patients are associated with …

Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic
development. In adults, it is involved in many pathological processes such as lymphedema …

There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …

Heterozygous germline mutations in the zinc finger transcription factor GATA2 have recently
been shown to underlie a range of clinical phenotypes, including Emberger syndrome, a …

Vascular endothelial growth factor C (VEGF‐C) binding to its tyrosine kinase receptor
VEGFR‐3 drives lymphatic vessel growth during development and in pathological …

Lymphatic vasculature drains interstitial fluids, which contain the tissue's waste products,
and ensures immune surveillance of the tissues, allowing immune cell recirculation. Until …

Patients with congenital lymphedema suffer from tissue swelling in part due to mutations in
genes regulating lymphatic valve development. Lymphatic valve leaflets grow and are …