Tryptophan is an essential amino acid critical for protein synthesis in humans that has
emerged as a key player in the microbiota-gut-brain axis. It is the only precursor for the …

Traumatic brain injury leads to cellular damage which in turn results in the rapid release of
damage-associated molecular patterns (DAMPs) that prompt resident cells to release …

The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …

Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the
least studied structures of the central nervous system (CNS) despite its clinical importance …

MRI-guided pulsed focused ultrasound (pFUS) combined with systemic infusion of
ultrasound contrast agent microbubbles (MB) causes localized blood–brain barrier (BBB) …

Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

There are numerous causes of a raised core temperature. A fever occurring in sepsis may
be associated with a survival benefit. However, this is not the case for non-infective triggers …

Within minutes of a traumatic impact, a robust inflammatory response is elicited in the injured
brain. The complexity of this post-traumatic squeal involves a cellular component …