Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …

Several epidemiological observations have shown an inverse relation between
consumption of plant-based foods, rich in phytochemicals, and incidence of cancer …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Abstract Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against
environmental stresses. Nrf2 induces the expression of detoxification and antioxidant …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Organismal life encounters reactive oxidants from internal metabolism and environmental
toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are …

Many studies of chemopreventive drugs have suggested that their beneficial effects on
suppression of carcinogenesis and many other chronic diseases are mediated through …

Senescent cells contribute to age‐related pathology and loss of function, and their selective
removal improves physiological function and extends longevity. Rapamycin, an inhibitor of …