Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes
that regulate the development and function of cells that line renal tubules. This review …

Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …

In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules in kidneys and other
organs. Human kidney organoids can reconstitute PKD cystogenesis in a genetically …

Mucolipidosis type IV (MLIV) is a developmental neurodegenerative disorder characterized
by severe neurologic and ophthalmologic abnormalities. The MLIV gene, ML4 (MCOLN1) …

One way of controlling the activity of E-cadherin–a protein that is, simultaneously, a major
cell-adhesion molecule, a powerful tumour suppressor, a determinant of cell polarity and a …

In plants, research on γ-aminobutyric acid (GABA) has focused on its role as a metabolite,
mainly in the context of responses to biotic and abiotic stresses. By contrast, studies of GABA …

As sequencing of the human genome nears completion, the genes that cause many human
diseases are being identified and functionally described. This has revealed that many …

Epithelial cells contain apical and basolateral surfaces with distinct compositions. Sorting of
certain proteins to the basolateral surface involves the epithelial-specific μ1b clathrin …

Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic
kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling …

Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder
characterized by severe psychomotor retardation and ophthalmologic abnormalities …