Protein-based bioactive coatings: from nanoarchitectonics to applications

C Fu, Z Wang, X Zhou, B Hu, C Li, P Yang - Chemical Society Reviews, 2024 - pubs.rsc.org
Protein-based bioactive coatings have emerged as a versatile and promising strategy for
enhancing the performance and biocompatibility of diverse biomedical materials and …

Material approaches to active tissue mechanics

W Xi, TB Saw, D Delacour, CT Lim… - Nature Reviews Materials, 2019 - nature.com
Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

Integer topological defects organize stresses driving tissue morphogenesis

P Guillamat, C Blanch-Mercader, G Pernollet… - Nature materials, 2022 - nature.com
Tissues acquire function and shape via differentiation and morphogenesis. Both processes
are driven by coordinating cellular forces and shapes at the tissue scale, but general …

Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection

D Adamoski, MM Dias, JEN Quesñay, Z Yang… - Nature structural & …, 2023 - nature.com
Glutaminase (GLS), which deaminates glutamine to form glutamate, is a mitochondrial
tetrameric protein complex. Although inorganic phosphate (Pi) is known to promote GLS …

Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates

RS Fischer, X Sun, MA Baird… - Proceedings of the …, 2021 - National Acad Sciences
Contact guidance is a powerful topographical cue that induces persistent directional cell
migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix …

Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies

M Toro-Nahuelpan, I Zagoriy, F Senger, L Blanchoin… - Nature …, 2020 - nature.com
Spatially controlled cell adhesion on electron microscopy supports remains a bottleneck in
specimen preparation for cellular cryo-electron tomography. Here, we describe contactless …

Convergence of microengineering and cellular self-organization towards functional tissue manufacturing

J Laurent, G Blin, F Chatelain, V Vanneaux… - Nature Biomedical …, 2017 - nature.com
Technical progress in materials science and bioprinting has for the past few decades
fostered considerable advances in medicine. More recently, the understanding of the …

Nanoscale surface topography reduces focal adhesions and cell stiffness by enhancing integrin endocytosis

X Li, LH Klausen, W Zhang, Z Jahed, CT Tsai, TL Li… - Nano …, 2021 - ACS Publications
Both substrate stiffness and surface topography regulate cell behavior through
mechanotransduction signaling pathways. Such intertwined effects suggest that engineered …

Engineering a tunable micropattern‐array assay to sort single extracellular vesicles and particles to detect RNA and protein in situ

J Zhang, XY Rima, X Wang… - Journal of …, 2023 - Wiley Online Library
The molecular heterogeneity of extracellular vesicles (EVs) and the co‐isolation of
physically similar particles, such as lipoproteins (LPs), confounds and limits the sensitivity of …

How cells respond to environmental cues–insights from bio-functionalized substrates

V Ruprecht, P Monzo, A Ravasio, Z Yue… - Journal of cell …, 2017 - journals.biologists.com
Biomimetic materials have long been the (he) art of bioengineering. They usually aim at
mimicking in vivo conditions to allow in vitro culture, differentiation and expansion of cells …