Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend
off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological …

Survivin is the smallest member of the inhibitor of apoptosis protein family, which has key
roles in regulating cell division and inhibiting apoptosis by blocking caspase activation …

The mitochondria-mediated caspase activation pathway is a major apoptotic pathway
characterized by mitochondrial outer membrane permeabilization (MOMP) and subsequent …

Underneath the intricacy of every cancer lies mysterious events that impel the tumour cell
and its posterity into abnormal growth and tissue invasion. Oncogenic mutations disturb the …

Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer
drugs. With small size (10–100 nm) and hydrophilic shell of PEG, polymeric micelles exhibit …

Achieving the activation of drugs within cellular systems may provide targeted therapies.
Here we construct a tumour-selective cascade activatable self-detained system (TCASS) …

Many diseases, especially cancers, result from aberrant or overexpression of pathogenic
proteins. Specific inhibitors against these proteins have shown remarkable therapeutic …

Systemic anticancer chemotherapy is immunosuppressive and mostly induces
nonimmunogenic tumor cell death. Here, we show that even in the absence of any adjuvant …