Identification of antifungal targets based on computer modeling

E Bencurova, SK Gupta, E Sarukhanyan, T Dandekar - Journal of Fungi, 2018 - mdpi.com
Aspergillus fumigatus is a saprophytic, cosmopolitan fungus that attacks patients with a
weak immune system. A rational solution against fungal infection aims to manipulate fungal …

Using evolutionary genomics, transcriptomics, and systems biology to reveal gene networks underlying fungal development

Z Wang, A Gudibanda, U Ugwuowo, F Trail… - Fungal Biology …, 2018 - Elsevier
Fungal model species have contributed to many aspects of modern biology, from
biochemistry and cell biology to molecular genetics. Nevertheless, only a few genes …

[HTML][HTML] A comprehensive transcription factor and DNA-binding motif resource for the construction of gene regulatory networks in Botrytis cinerea and Trichoderma …

C Olivares-Yañez, E Sánchez, G Pérez-Lara… - Computational and …, 2021 - Elsevier
Botrytis cinerea and Trichoderma atroviride are two relevant fungi in agricultural systems. To
gain insights into these organisms' transcriptional gene regulatory networks (GRNs), we …

[PDF][PDF] Host responses to Candida albicans. A review

E Zdanavičienė, J Sakalauskienė, A Gleiznys… - Stomatologija, 2017 - sbdmj.com
Candida albicans is the most prevalent human fungal pathogen, that is component of the
commensal microbial flora of the mouth. Under certain conditions, C. albicans can cause …

PHI-Nets: A network resource for Ascomycete fungal pathogens to annotate and identify putative virulence interacting proteins and siRNA targets

EI Janowska-Sejda, A Lysenko, M Urban… - Frontiers in …, 2019 - frontiersin.org
Interactions between proteins underlie all aspects of complex biological mechanisms.
Therefore, methodologies based on complex network analyses can facilitate identification of …

A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen

CC Carriel, S Pyne, SA Halberg-Spencer, SC Park… - bioRxiv, 2023 - biorxiv.org
Aspergillus fumigatus is a notorious pathogenic fungus responsible for various harmful,
sometimes lethal, diseases known as aspergilloses. Understanding the gene regulatory …

[PDF][PDF] Unraveling chitin signaling in fungi: Insights into Lipo-chitooligosaccharides, LysM Effectors, and Regulatory Networks in Aspergillus fumigatus

CXC Carriel - 2024 - asset.library.wisc.edu
In 2019, researchers revealed that most fungi secrete chitin-based signaling molecules
called lipo-chitooligosaccharides (LCOs). This finding upended the long-held belief that …

A Text Mining Protocol for Mining Biological Pathways and Regulatory Networks from Biomedical Literature

S Abdulkadhar, J Natarajan - Biomedical Text Mining, 2022 - Springer
A biological pathway or regulatory network is a collection of molecular regulators which can
activate the changes in cellular processes leading to an assembly of new molecules by …