Progress in the mechanism and targeted drug therapy for COPD
C Wang, J Zhou, J Wang, S Li, A Fukunaga… - … and Targeted Therapy, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD) is emphysema and/or chronic bronchitis
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
characterised by long-term breathing problems and poor airflow. The prevalence of COPD …
Pulmonary macrophages: a new therapeutic pathway in fibrosing lung disease?
Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or
respiratory failure and has an average life expectancy of 3 years from diagnosis …
respiratory failure and has an average life expectancy of 3 years from diagnosis …
Animal models of fibrotic lung disease
B B. Moore, WE Lawson, TD Oury… - American journal of …, 2013 - atsjournals.org
Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure,
as a result of genetic defects, and after trauma or acute lung injury leading to …
as a result of genetic defects, and after trauma or acute lung injury leading to …
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
Different animal models of pulmonary fibrosis have been developed to investigate potential
therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model …
therapies for idiopathic pulmonary fibrosis (IPF). The most common is the bleomycin model …
Murine models of pulmonary fibrosis
BB Moore, CM Hogaboam - American Journal of …, 2008 - journals.physiology.org
Human pulmonary fibrosis is characterized by alveolar epithelial cell injury, areas of type II
cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of …
cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of …
Immunomodulatory roles of surfactant proteins A and D: implications in lung disease
AM Pastva, JR Wright, KL Williams - Proceedings of the American …, 2007 - atsjournals.org
Surfactant, a lipoprotein complex, was originally described for its essential role in reducing
surface tension at the air–liquid interface of the lung; however, it is now recognized as being …
surface tension at the air–liquid interface of the lung; however, it is now recognized as being …
Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages
EF Redente, RC Keith, W Janssen… - American journal of …, 2014 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a relentless, fibrotic parenchymal lung disease in which
alternatively programmed macrophages produce profibrotic molecules that promote …
alternatively programmed macrophages produce profibrotic molecules that promote …
Tumor necrosis factor–α overexpression in lung disease: a single cause behind a complex phenotype
LKA Lundblad, J Thompson-Figueroa… - American journal of …, 2005 - atsjournals.org
Rationale: Tumor necrosis factor α (TNF-α) has been implicated as a key cytokine in many
inflammatory lung diseases. These effects are currently unclear, because a transgenic …
inflammatory lung diseases. These effects are currently unclear, because a transgenic …
Obesity and the development of lung fibrosis
X Guo, C Sunil, G Qian - Frontiers in pharmacology, 2022 - frontiersin.org
Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory
complications including fibrotic changes in the lung. The influence of obesity on the lung is …
complications including fibrotic changes in the lung. The influence of obesity on the lung is …
TNF‐α induces TGF‐β1 expression in lung fibroblasts at the transcriptional level via AP‐1 activation
DE Sullivan, MB Ferris, H Nguyen… - Journal of cellular …, 2009 - Wiley Online Library
Tumour necrosis factor‐α (TNF‐α) and transforming growth factor‐β1 (TGF‐β1) are peptides
with multiple biological activities that influence neoplastic, immunologic and fibroproliferative …
with multiple biological activities that influence neoplastic, immunologic and fibroproliferative …