Retinal cell degeneration in animal models

M Niwa, H Aoki, A Hirata, H Tomita, PG Green… - International journal of …, 2016 - mdpi.com
The aim of this review is to provide an overview of various retinal cell degeneration models
in animal induced by chemicals (N-methyl-d-aspartate-and CoCl2-induced), autoimmune …

Endogenous neuroprotective molecules and their mechanisms in the central nervous system

H Hayashi, N Takagi - Biological and Pharmaceutical Bulletin, 2015 - jstage.jst.go.jp
Functions of the central nervous system (CNS) are based on a complex neural network. It is
believed that the CNS has several neuroprotective mechanisms operated by neurons, glia …

Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice

H Ueda, H Neyama, K Sasaki, C Miyama… - Neurobiology of Pain, 2019 - Elsevier
We developed a mouse model for central post-stroke pain (CPSP), a centrally-originated
neuropathic pain (NeuP). In this mode, mice were first injected with Rose Bengal, followed …

Retinal cell type‐specific prevention of ischemia‐induced damages by LPS‐TLR 4 signaling through microglia

SK Halder, H Matsunaga, KJ Ishii, S Akira… - Journal of …, 2013 - Wiley Online Library
Reprogramming of toll‐like receptor 4 (TLR 4) by brief ischemia or lipopolysacharide (LPS)
contributes to superintending tolerance against destructive ischemia in brain. However …

Lumbosacral spinal proteomic changes during PAR4-induced persistent bladder pain

S Ye, NM Agalave, F Ma, DFD Mahmood, A Al-Grety… - Neuroscience …, 2024 - Elsevier
Repeated intravesical activation of protease-activated receptor-4 (PAR4) in mice results in
persistent bladder hyperalgesia (BHA). We investigated spinal proteomic changes …

MIF inhibitor ISO-1 protects photoreceptors and reduces gliosis in experimental retinal detachment

B Kim, R Kusibati, T Heisler-Taylor, D Mantopoulos… - Scientific reports, 2017 - nature.com
Photoreceptor death and retinal gliosis underlie the majority of vision threatening retinal
diseases including retinal detachment (RD). Although the underlying pathobiology of vision …

Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia–reperfusion

H Ueda, SK Halder, H Matsunaga, K Sasaki, S Maeda - Neuroscience, 2016 - Elsevier
Prothymosin alpha (ProTα) has robustness roles against brain and retinal ischemia or serum-
starvation stress. In the ProTα sequence, the active core 30-amino acid peptide/P 30 (aa 49 …

Prothymosin alpha and its mimetic hexapeptide improve delayed tissue plasminogen activator‐induced brain damage following cerebral ischemia

SK Halder, H Matsunaga, H Ueda - Journal of Neurochemistry, 2020 - Wiley Online Library
Tissue plasminogen activator (tPA) administration beyond 4.5 h of stroke symptoms is
beneficial for patients but has an increased risk of cerebral hemorrhage. Thus, increasing …

Deciphering cellular biological processes to clinical application: a new perspective for Tα1 treatment targeting multiple diseases

C Matteucci, A Argaw-Denboba… - Expert Opinion on …, 2018 - Taylor & Francis
Background: Thymosin alpha 1 (Tα1) is a well-recognized immune response modulator in a
wide range of disorders, particularly infections and cancer. The bioinformatic analysis of …

Prothymosin α Variants Isolated From CD8+ T Cells and Cervicovaginal Fluid Suppress HIV-1 Replication Through Type I Interferon Induction

A Teixeira, B Yen, GL Gusella… - The Journal of …, 2015 - academic.oup.com
Soluble factors from CD8+ T cells and cervicovaginal mucosa of women are recognized as
important in controlling human immunodeficiency virus type 1 (HIV-1) infection and …