SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

Background and Aims Because of a paucity of effective treatment options, metastasis is still
a major cause for HCC‐associated mortality. The molecular mechanism of inflammation …

Ferroptosis is a novel form of programmed cell death, and it is characterized by iron-
dependent oxidative damage, lipid peroxidation and reactive oxygen species accumulation …

Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …

Abstract Background Ginsenoside Re is an active component in ginseng that confers
protection against myocardial ischemia/reperfusion (I/R) injury. Ferroptosis is a type of …

Programmed cell death (PCD) plays an important role in many aspects of individual
development, maintenance of body homeostasis and pathological processes. Ferroptosis is …

Solute carrier family 7 member 11 (SLC7A11) is a major transporter regulating cysteine
metabolism and is widely expressed in a variety of tumor cells. SLC7A11 plays an important …

Pancreatic cancer is a gastrointestinal tumor with a high mortality rate, and advances in
surgical procedures have only resulted in limited improvements in the prognosis of patients …

Background: Ferroptosis induced by SLC7A11 has an important translational value in the
treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon …