Fever is a cardinal symptom of infectious or inflammatory insults, but it can also arise from
noninfectious causes. The fever-inducing agent that has been used most frequently in …

The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1)
channel as pain therapeutics has revealed that these compounds cause hyperthermia in …

Rationale: Hyperventilation of hot humid air induces transient bronchoconstriction in patients
with asthma; the underlying mechanism is not known. Recent studies showed that an …

The innate immune system serves as the first line of host defense against the deleterious
effects of invading infectious pathogens. Fever is the hallmark among the defense …

Sensory nerves innervating the lung and airways play an important role in regulating various
cardiopulmonary functions and maintaining homeostasis under both healthy and disease …

Endotoxic fever is regulated by endogenous factors that provide pro-and anti-pyretic signals
at different points along the febrigenic pathway, from the periphery to the brain. Current …

Previous studies have disagreed about whether prostaglandin EP1 or EP3 receptors are
critical for producing febrile responses. We therefore injected lipopolysaccharide (LPS) at a …

Despite the wealth of evidence in animals that immune activation has a key role in the
development and maintenance of chronic pain, evidence to support this in humans is scant …

Introduction 3. EP receptors in the PGE2-sensitive febrogenic zone 3.1. PGE2 sensitive
febrogenic zone 3.2. EP receptor distribution within the OVLT/POA region 3.3. Activated EP …

Extensive evidence indicates that several types of temperature-sensitive ion channels are
abundantly expressed in the sensory nerves innervating airway mucosa. Indeed, airway …