Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

Rationale An increasingly compelling literature points to a major role for the glutamate
system in mediating the effects of alcohol on behavior and the pathophysiology of …

Alcoholism is a serious public health concern that is characterized by the development of
tolerance to alcohol's effects, increased consumption, loss of control over drinking and the …

Current pharmacotherapies for addiction represent opportunities for facilitating treatment
and are forming a foundation for evaluating new medications. Furthermore, validated animal …

Rationale Exposure to inescapable stressors increases both the rewarding properties and
self-administration of cocaine through the signaling of the kappa-opioid receptor (KOR), but …

This review represents the focus of a symposium that was presented at the “Alcoholism and
Stress: A Framework for Future Treatment Strategies” conference in Volterra, Italy on May 3 …

Patients suffering from opioid use disorder often relapse during periods of abstinence, which
is posited to be caused by negative affective states that drive motivated behaviors. Here, we …

The metabotropic glutamate receptor 5 (mGlu5) has been implicated in ethanol-and drug-
seeking behaviours in rodent studies. Here we examine a number of ethanol-related …

The previous scenario is based on a first-person recollection of attending a party that was
developed into a virtual reality scenario by Dr. Bordnick at the Virtual Reality Clinical …

This review discusses recent research of mood disorders associated with the cessation of
psychoactive substances, with an emphasis on preclinical studies that have been published …