The cholinergic hypothesis of cognitive impairment and Alzheimer's disease has been for
decades a “polar star” for studies on dementia and neurodegenerative diseases. Aim of the …

Animal models aim to replicate the symptoms, the lesions or the cause (s) of Alzheimer
disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its …

We identified axonal defects in mouse models of Alzheimer's disease that preceded known
disease-related pathology by more than a year; we observed similar axonal defects in the …

Alzheimer's disease (AD), the major contributor to dementia in the elderly, involves
accumulation in the brain of extracellular plaques containing the β-amyloid protein (Aβ) and …

Dementia is a major cause of disability amongst the elderly and represents a serious global
health issue. Current treatments for dementia are limited; at best they provide inadequate …

Alzheimer's disease, the most common neurodegenerative disorder of senile dementia, is
characterized by two major morpho-pathological hallmarks. Deposition of extracellular …

Alzheimer's Disease (AD) is a neurodegenerative disorder that is characterized by
extracellular deposits of amyloid-β peptide (Aβ) and a severe depletion of the cholinergic …

Alzheimer's disease is the leading cause of dementia in the elderly, presenting itself
clinically by progressive loss of memory and learning. Since synaptic density correlates …

BACE1 is a key enzyme in the generation of Aβ, the major component of senile plaques in
the brains of Alzheimer's disease patients. We have generated transgenic mice expressing …

In 7-month-old TgCRND8 mice, the extracellular cortical acetylcholine levels in vivo, the
number and morphology of cholinergic neurons in the nucleus basalis magnocellularis and …