Simple Summary BRPF1 (also named as BR140) was identified 28 years ago, and it was not
until the past 5 years that its mutations in humans caught increasing attention. Those …

Acetylation of lysine residues on histone tails is an important post-translational modification
(PTM) that regulates chromatin dynamics to allow gene transcription as well as DNA …

Epigenetic integrity is critical for many eukaryotic cellular processes. An important question
is how different epigenetic regulators control development and influence disease. Lysine …

Identification of over 500 epigenetic regulators in humans raises an interesting question
regarding how chromatin dysregulation contributes to different diseases. Bromodomain and …

The development of taxane resistance remains a major challenge for castration resistant
prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient …

Epigenetic deregulation plays an essential role in hepatocellular carcinoma (HCC)
progression. Bromodomains are epigenetic “readers” of histone acetylation. Recently …

Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes
with bromodomain-and PHD finger-containing protein 1 (BRPF1) for acetylation of histone …

The BRPF (bromodomain and PHD finger-containing) family are scaffolding proteins
important for the recruitment of histone acetyltransferases of the MYST family to chromatin …

Abstract α-Tubulin acetyltransferase 1 (ATAT1) catalyzes acetylation of α-tubulin at lysine 40
in various organisms ranging from Tetrahymena to humans. Despite the importance in …

The assembly of human histone acetyltransferase MOZ/MORF complexes relies on the
scaffolding bromodomain plant homeodomain (PHD) finger 1 (BRPF1) subunit. The PHD …