Abstract Mannose-capped lipoarabinomannan (ManLAM), present in all members of the
Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high …

The Mycobacterium tuberculosis cell envelope has been evolving over time to make the
bacterium transmissible and adaptable to the human host. In this context, the M. tuberculosis …

To fight tuberculosis, better vaccination strategies are needed. Live attenuated
Mycobacterium tuberculosis-derived vaccine, MTBVAC, is a promising candidate in the …

Growing old is associated with an increase in the basal inflammatory state of an individual
and susceptibility to many diseases, including infectious diseases. Evidence is growing to …

The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of
Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses …

ABSTRACT Bacillus Calmette-Guérin (BCG) is the only licensed vaccine against
tuberculosis (TB). However, BCG has variable efficacy and cannot completely prevent TB …

In TB, combat between the human host and Mycobacterium tuberculosis involves intricate
interactions with immune cells. M. tuberculosis has evolved a complex evasion system to …

The absence of validated correlates of protection (CoPs) hampers the rational design and
clinical development of new tuberculosis vaccines. In this review, we provide an overview of …

As we age, there is an increased risk for the development of tuberculosis (TB) caused by
Mycobacterium tuberculosis (Mtb) infection. Few studies consider that age-associated …

The elderly population is highly susceptible to developing respiratory diseases, including
tuberculosis, a devastating disease caused by the airborne pathogen Mycobacterium …