Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

DHX9 is member of the DExD/H-box family of helicases with a “DEIH” sequence at its
eponymous DExH-box motif. Initially purified from human and bovine cells and identified as …

RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and
yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To …

Interactions between noncoding RNAs and chromatin proteins play important roles in gene
regulation, but the molecular details of most of these interactions are unknown. Using …

Therapy-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive subtype
of prostate cancer with poor patient survival. Emerging evidence indicates that t-NEPC can …

Background & Aims Genome-wide association studies (GWASs) have associated
approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third of these loci …

After transcription, RNAs are always associated with RNA binding proteins (RBPs) to
perform biological activities. RBPs can interact with target RNAs in sequence-and structure …

Cancer is one of the most studied areas of human biology over the past century. Despite
having attracted much attention, hype, and investments, the search to find a cure for cancer …

Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces
durable anti-tumor immune responses via T cell recognition of some elusive oncofetal …

L1TD1 is a cytoplasmic RNA-binding protein specifically expressed in pluripotent stem cells
and, unlike its mouse ortholog, is essential for the maintenance of stemness in human cells …