Present status of microfluidic PCR chip in nucleic acid detection and future perspective

S Chen, Y Sun, F Fan, S Chen, Y Zhang… - TrAC Trends in …, 2022 - Elsevier
Polymerase chain reaction (PCR) amplifies specific fragment of DNA molecules and has
been extensively applied in fields of pathogens and gene mutation detection, food safety …

Towards a point-of-care SERS sensor for biomedical and agri-food analysis applications: A review of recent advancements

J Perumal, Y Wang, ABE Attia, US Dinish, M Olivo - Nanoscale, 2021 - pubs.rsc.org
The growing demand for reliable and robust methodology in bio-chemical sensing calls for
the continuous advancement of sensor technologies. Over the last two decades, surface …

[HTML][HTML] Exosome detection via surface-enhanced Raman spectroscopy for cancer diagnosis

J Li, Y Li, P Li, Y Zhang, L Du, Y Wang, C Zhang… - Acta biomaterialia, 2022 - Elsevier
As nanoscale extracellular vesicles, exosomes are secreted by various cell types, and they
are widely distributed in multiple biological fluids. Studies have shown that tumor-derived …

[PDF][PDF] Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip

S Bai, X Ren, K Obata, Y Ito, K Sugioka - Opto-Electronic Advances, 2022 - researching.cn
Surface-enhanced Raman scattering (SERS), owing to its high sensitivity based on localized
surface plasmon resonance of nanostructured metals, is recently attracting much attention to …

Nanomaterial-based microfluidic systems for cancer biomarker detection: recent applications and future perspectives

Y Xiang, C Hu, G Wu, S Xu, Y Li - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Detecting cancer biomarkers (eg, circulating tumor cells, extracellular vehicles, nucleic
acids, and protein biomarkers) is vital for risk assessment and early diagnosis. Nanomaterial …

High throughput blood analysis based on deep learning algorithm and self‐positioning super‐hydrophobic SERS platform for non‐invasive multi‐disease screening

X Lin, D Lin, Y Chen, J Lin, S Weng… - Advanced Functional …, 2021 - Wiley Online Library
Blood analysis is crucial for early cancer screening and improving patient survival rates.
However, developing an effective strategy for early cancer detection using high‐throughput …

CRISPR-/Cas12a-mediated liposome-amplified strategy for the surface-enhanced Raman scattering and naked-eye detection of nucleic acid and application to food …

J Liu, J Chen, D Wu, M Huang, J Chen, R Pan… - Analytical …, 2021 - ACS Publications
Surface-enhanced Raman scattering (SERS) has been recognized as a powerful tool for
biosensors due to the ultrahigh sensitivity and unique fingerprint information. However, there …

Seed-mediated synthesis of gold nanorods at low concentrations of CTAB

MZ Wei, TS Deng, Q Zhang, Z Cheng, S Li - ACS omega, 2021 - ACS Publications
Although gold nanorods capped with hexadecyltrimethylammonium bromide (CTAB) have
been prepared through the seed-mediated method for their use in diagnostics and …

Surface enhanced Raman spectroscopy for DNA biosensors—How far are we?

E Pyrak, J Krajczewski, A Kowalik, A Kudelski… - Molecules, 2019 - mdpi.com
A sensitive and accurate identification of specific DNA fragments (usually containing a
mutation) can influence clinical decisions. Standard methods routinely used for this type of …

Discriminatory detection of ssDNA by surface-enhanced Raman spectroscopy (SERS) and tree-based support vector machine (Tr-SVM)

S Kang, I Kim, PJ Vikesland - Analytical Chemistry, 2021 - ACS Publications
We report label-free detection of 86-base single-stranded DNA (ssDNA) gene segments by
surface-enhanced Raman spectroscopy (SERS). The use of a slippery liquid infused porous …