Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …
the globe and cause severe associated problems like kidney disorders, heart and nervous …
Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
A Toumi, S Boudriga, K Hamden, M Sobeh… - Bioorganic …, 2021 - Elsevier
In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes
mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine …
mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine …
A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity
LM Aroua, HR Almuhaylan, FM Alminderej… - Bioorganic …, 2021 - Elsevier
Synthetic routes to a series of benzoylarylbenzimidazol 3a-h have been derived from 3, 4-
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
A review on the antimicrobial assessment of triazole-azomethine functionalized frameworks incorporating transition metals
Antimicrobial resistance is a growing threat to global public health that calls for innovative
strategies to develop new methods of action against resistance to emerging infectious …
strategies to develop new methods of action against resistance to emerging infectious …
Synthesis, biological evaluation and action mechanism of 7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-phenylhydrazone derivatives as α-glucosidase inhibitors
Q Feng, J Zhang, S Luo, Y Huang, Z Peng… - European Journal of …, 2023 - Elsevier
In our work, several 7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-phenylhydrazone
derivatives as α-glucosidase inhibitors (α-GIs) were synthesized and characterized by 1 H …
derivatives as α-glucosidase inhibitors (α-GIs) were synthesized and characterized by 1 H …
Computational investigation of molecular structures, spectroscopic properties, cholinesterase inhibition and antibacterial activities of triazole Schiff bases endowed …
The aim of this project was to introduce novel bioactive compounds through the design and
synthesis of two mono-Schiff bases, 4-[(5-amino-1H-1, 2, 4-triazol-3-yl) imino] …
synthesis of two mono-Schiff bases, 4-[(5-amino-1H-1, 2, 4-triazol-3-yl) imino] …
Dynamics of small molecule-enzyme interactions: Novel benzenesulfonamides as multi-target agents endowed with inhibitory effects against some metabolic …
In contemporary medicinal chemistry, employing a singular small molecule to concurrently
multi-target disparate molecular entities is emerging as a potent strategy in the ongoing …
multi-target disparate molecular entities is emerging as a potent strategy in the ongoing …
Evaluation of synthetic 2-aryl quinoxaline derivatives as α-amylase, α-glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitors
Variety of 2-aryl quinoxaline derivatives 1–23 were synthesized in good yields, by reacting
1, 2-phenylenediamine with varyingly substituted phenacyl bromides in the presence of …
1, 2-phenylenediamine with varyingly substituted phenacyl bromides in the presence of …
Design, synthesis, biological evaluation, and docking study of new triazole-phenylacetamide derivatives as α-glucosidase inhibitors
S Luo, W Yang, Y Huang, Z Peng, G Wang - Bioorganic Chemistry, 2023 - Elsevier
To discover potent α-glucosidase inhibitors, a class of novel triazole-phenylacetamide
derivatives (5a-5p) were designed, prepared, and tested for their α-glucosidase inhibitory …
derivatives (5a-5p) were designed, prepared, and tested for their α-glucosidase inhibitory …