A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Retroviral infection delivers an RNA genome into the cytoplasm that serves as the template
for the synthesis of a linear double-stranded DNA copy by the viral reverse transcriptase …

The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment
the core is released into the cytoplasm, it interacts with a range of cellular factors that …

Background The murine leukemia virus (MLV) has been a powerful model of pathogenesis
for the discovery of genes involved in cancer. Its splice donor (SD')-associated retroelement …

Tethering of viral genomes to host chromosomes has been recognized in a variety of DNA
and RNA viruses. It can occur during both the productive cycle and latent infection and may …

Retroviral reverse transcription starts within the capsid and uncoating and reverse
transcription are mutually dependent. There is still debate regarding the timing and cellular …

The p12 region of murine leukemia virus (MLV) Gag and the p6 region of HIV-1 Gag contain
late domains required for virus budding. Additionally, the accessory protein Vpr is recruited …

Moloney murine leukemia virus (MLV) infects BALB/c mice and induces T-cell lymphoma in
mice. Retroviral integration is mediated by the interaction of the MLV integrase (IN) with …

Chromatin structure and dynamics regulate key cellular processes such as DNA replication,
transcription, repair, remodeling, and gene expression, wherein different protein factors …

Retroviruses must selectively recognize their unspliced RNA genome (gRNA) among
abundant cellular and spliced viral RNAs to assemble into newly formed viral particles …