Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

Attention‐deficit/hyperactivity disorder (ADHD) and tobacco smoking are among the most
common and costly psychiatric and behavioral problems. The rates of co‐occurrence of …

We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-
analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence …

Purpose of review: To provide an overview of the underlying neurobiology of tobacco
smoking in schizophrenia, and implications for treatment of this comorbidity. Recent findings …

Several independent studies show that the chromosome 15q25. 1 region, which contains
the CHRNA5–CHRNA3–CHRNB4 gene cluster, harbors variants strongly associated with …

Highlights•PUI is an increasing problem in mental health around the globe.•PUI shares
some clinical similarities with other substance-related disorders.•Candidate genes of the …

Nicotine addiction and alcohol dependence are highly comorbid disorders that are likely to
share overlapping genetic components. We have examined two neuronal nicotinic receptor …

Although the efficacy of pharmacotherapy for tobacco dependence has been previously
demonstrated, there is substantial variability among individuals in treatment response. We …

Nicotine is the major neurotoxicant in cigarettes that affects many transmitter systems within
the brain as well as other factors, including the growth factors. Brain derived neurotrophic …

BACKGROUND: Brain-derived neurotrophic factor (BDNF) is putatively involved in the
pathophysiology of depression. This study examined associations between BDNF genotype …