Artificial intelligence tools for the identification of antibiotic resistance genes

I Olatunji, DKR Bardaji, RR Miranda… - Frontiers in …, 2024 - frontiersin.org
The fight against bacterial antibiotic resistance must be given critical attention to avert the
current and emerging crisis of treating bacterial infections due to the inefficacy of clinically …

Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

AK Pöntinen, J Top, S Arredondo-Alonso… - Nature …, 2021 - nature.com
Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous
in animals and insects, representing a classical generalist microorganism. Here, we study E …

Distinct increase in antimicrobial resistance genes among Escherichia coli during 50 years of antimicrobial use in livestock production in China

L Yang, Y Shen, J Jiang, X Wang, D Shao, MMC Lam… - Nature Food, 2022 - nature.com
Antimicrobial use in livestock production is linked to the emergence and spread of
antimicrobial resistance (AMR), but large-scale studies on AMR changes in livestock …

Experimental approaches to tracking mobile genetic elements in microbial communities

CC Saak, CB Dinh, RJ Dutton - FEMS Microbiology Reviews, 2020 - academic.oup.com
Horizontal gene transfer is an important mechanism of microbial evolution and is often
driven by the movement of mobile genetic elements between cells. Due to the fact that …

Plasmids shaped the recent emergence of the major nosocomial pathogen Enterococcus faecium

S Arredondo-Alonso, J Top, A McNally, S Puranen… - MBio, 2020 - Am Soc Microbiol
Enterococcus faecium is a gut commensal of humans and animals but is also listed on the
WHO global priority list of multidrug-resistant pathogens. Many of its antibiotic resistance …

PPR-Meta: a tool for identifying phages and plasmids from metagenomic fragments using deep learning

Z Fang, J Tan, S Wu, M Li, C Xu, Z Xie, H Zhu - Gigascience, 2019 - academic.oup.com
Background Phages and plasmids are the major components of mobile genetic elements,
and fragments from such elements generally co-exist with chromosome-derived fragments in …

Cellular compartmentation of nickel in the hyperaccumulators Alyssum lesbiacum, Alyssum bertolonii and Thlaspi goesingense

H Küpper, E Lombi, FJ Zhao… - Journal of …, 2001 - academic.oup.com
Nickel uptake and cellular compartmentation were investigated in three Ni
hyperaccumulators: Alyssum bertolonii (Desv), Alyssum lesbiacum (Candargy) and Thlaspi …

Interplay between the cell envelope and mobile genetic elements shapes gene flow in populations of the nosocomial pathogen Klebsiella pneumoniae

M Haudiquet, A Buffet, O Rendueles, EPC Rocha - PLoS Biology, 2021 - journals.plos.org
Mobile genetic elements (MGEs) drive genetic transfers between bacteria using
mechanisms that require a physical interaction with the cellular envelope. In the high-priority …

Horizontally acquired papGII-containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages

M Biggel, BB Xavier, JR Johnson, KL Nielsen… - Nature …, 2020 - nature.com
Escherichia coli is the leading cause of urinary tract infection, one of the most common
bacterial infections in humans. Despite this, a genomic perspective is lacking regarding the …

Platon: identification and characterization of bacterial plasmid contigs in short-read draft assemblies exploiting protein sequence-based replicon distribution scores

O Schwengers, P Barth, L Falgenhauer… - Microbial …, 2020 - microbiologyresearch.org
Plasmids are extrachromosomal genetic elements that replicate independently of the
chromosome and play a vital role in the environmental adaptation of bacteria. Due to …