Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine
development strategies are often difficult to apply to parasites, leaving an immense unmet …

Bioethanol is the largest biotechnology product and the most dominant biofuel globally.
Saccharomyces cerevisiae is the most favored microorganism employed for its industrial …

There is an urgent need to make drug discovery cheaper and faster. This will enable the
development of treatments for diseases currently neglected for economic reasons, such as …

Malaria, caused by parasites of the genus Plasmodium, leads to over half a million deaths
per year, 90% of which are caused by Plasmodium falciparum. P. vivax usually causes …

Background The uptake of drugs into cells has traditionally been considered to be
predominantly via passive diffusion through the bilayer portion of the cell membrane. The …

Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and
chronic parasitic ailment that affects> 240 million people in 70 countries worldwide. It is the …

Plasmodium falciparum, the most deadly agent of malaria, displays a wide variety of
resistance mechanisms in the field. The ability of antimalarial compounds in development to …

Metabolic pathways that extract energy from carbon compounds are essential for an
organism's survival. Therefore, inhibition of enzymes in these pathways represents a …

Pneumocystis jirovecii is a fungal pathogen that causes pneumocystis pneumonia, a
disease that mainly affects immunocompromised individuals. This fungus has historically …

Background Lymphatic filariasis is caused by the parasitic worms Wuchereria bancrofti,
Brugia malayi or B. timori, which are transmitted via the bites from infected mosquitoes. Once …