Alternative splicing as a source of phenotypic diversity

CJ Wright, CWJ Smith, CD Jiggins - Nature Reviews Genetics, 2022 - nature.com
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

Alternative splicing regulatory networks: functions, mechanisms, and evolution

J Ule, BJ Blencowe - Molecular cell, 2019 - cell.com
High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Communicating clocks shape circadian homeostasis

KB Koronowski, P Sassone-Corsi - Science, 2021 - science.org
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Alternative‐splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

LM Urbanski, N Leclair… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Rapid and dynamic alternative splicing impacts the Arabidopsis cold response transcriptome

CPG Calixto, W Guo, AB James, NA Tzioutziou… - The Plant …, 2018 - academic.oup.com
Plants have adapted to tolerate and survive constantly changing environmental conditions
by reprogramming gene expression The dynamics of the contribution of alternative splicing …

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

CM Greco, KB Koronowski, JG Smith, J Shi… - Science …, 2021 - science.org
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …

Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences

D Bergeron, L Faucher-Giguère, AK Emmerichs… - Genome Biology, 2023 - Springer
Abstract Background Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best
known for their involvement in ribosomal RNA maturation. In mammals, most expressed …

Lnc RNA‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation

K Ninomiya, S Adachi, T Natsume, J Iwakiri… - The EMBO …, 2020 - embopress.org
A number of long noncoding RNA s (lnc RNA s) are induced in response to specific stresses
to construct membrane‐less nuclear bodies; however, their function remains poorly …

A conserved kinase-based body-temperature sensor globally controls alternative splicing and gene expression

T Haltenhof, A Kotte, F De Bortoli, S Schiefer, S Meinke… - Molecular Cell, 2020 - cell.com
Homeothermic organisms maintain their core body temperature in a narrow, tightly
controlled range. Whether and how subtle circadian oscillations or disease-associated …

Co-transcriptional gene regulation in eukaryotes and prokaryotes

M Shine, J Gordon, L Schärfen, D Zigackova… - … Reviews Molecular Cell …, 2024 - nature.com
Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …