Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
Alternative splicing regulatory networks: functions, mechanisms, and evolution
J Ule, BJ Blencowe - Molecular cell, 2019 - cell.com
High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …
Communicating clocks shape circadian homeostasis
KB Koronowski, P Sassone-Corsi - Science, 2021 - science.org
BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …
Alternative‐splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
LM Urbanski, N Leclair… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
Rapid and dynamic alternative splicing impacts the Arabidopsis cold response transcriptome
CPG Calixto, W Guo, AB James, NA Tzioutziou… - The Plant …, 2018 - academic.oup.com
Plants have adapted to tolerate and survive constantly changing environmental conditions
by reprogramming gene expression The dynamics of the contribution of alternative splicing …
by reprogramming gene expression The dynamics of the contribution of alternative splicing …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences
D Bergeron, L Faucher-Giguère, AK Emmerichs… - Genome Biology, 2023 - Springer
Abstract Background Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best
known for their involvement in ribosomal RNA maturation. In mammals, most expressed …
known for their involvement in ribosomal RNA maturation. In mammals, most expressed …
Lnc RNA‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
A number of long noncoding RNA s (lnc RNA s) are induced in response to specific stresses
to construct membrane‐less nuclear bodies; however, their function remains poorly …
to construct membrane‐less nuclear bodies; however, their function remains poorly …
A conserved kinase-based body-temperature sensor globally controls alternative splicing and gene expression
T Haltenhof, A Kotte, F De Bortoli, S Schiefer, S Meinke… - Molecular Cell, 2020 - cell.com
Homeothermic organisms maintain their core body temperature in a narrow, tightly
controlled range. Whether and how subtle circadian oscillations or disease-associated …
controlled range. Whether and how subtle circadian oscillations or disease-associated …
Co-transcriptional gene regulation in eukaryotes and prokaryotes
M Shine, J Gordon, L Schärfen, D Zigackova… - … Reviews Molecular Cell …, 2024 - nature.com
Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …