A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

BACKGROUND Life-forms ranging from bacteria to humans are programmed by circadian
clocks—mechanisms that impose an~ 24-hour rhythmicity on biology in harmony with …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Plants have adapted to tolerate and survive constantly changing environmental conditions
by reprogramming gene expression The dynamics of the contribution of alternative splicing …

The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …

Abstract Background Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best
known for their involvement in ribosomal RNA maturation. In mammals, most expressed …

A number of long noncoding RNA s (lnc RNA s) are induced in response to specific stresses
to construct membrane‐less nuclear bodies; however, their function remains poorly …

Homeothermic organisms maintain their core body temperature in a narrow, tightly
controlled range. Whether and how subtle circadian oscillations or disease-associated …

Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …