Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: a …
Given the moderate efficacy of the currently available antidepressants (ADs) in the treatment
of major depressive disorder (MDD), the identification of agents that are both able to …
of major depressive disorder (MDD), the identification of agents that are both able to …
Current investigational drugs for major depression
SK Kulkarni, A Dhir - Expert opinion on investigational drugs, 2009 - Taylor & Francis
Background: The World Health Organization (WHO) report has predicted that major
depression will become a key cause of illness-induced disability by the year 2020, second …
depression will become a key cause of illness-induced disability by the year 2020, second …
Depressive-like behavior induced by tumor necrosis factor-α in mice
Pro-inflammatory cytokines are implicated in the pathogenesis of depression. However, few
animal models of cytokine-induced depression well characterized regarding its response to …
animal models of cytokine-induced depression well characterized regarding its response to …
Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice
EH Taniguti, YS Ferreira, IJV Stupp… - Brain research …, 2019 - Elsevier
Clinical and pre-clinical evidences indicate an association between inflammation and
depression since increased levels of pro-inflammatory cytokines are associated with …
depression since increased levels of pro-inflammatory cytokines are associated with …
Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways
I Holzmann, LM da Silva, JAC da Silva… - Pharmacology …, 2015 - Elsevier
Olfactory bulbectomy (OB) is an animal model of depression that can mimic symptoms that
are characteristic of depressive patients, such as behavioral, neurochemical and …
are characteristic of depressive patients, such as behavioral, neurochemical and …
Folic acid prevents depressive-like behavior and hippocampal antioxidant imbalance induced by restraint stress in mice
Experimental and epidemiological studies have shown the close relationship between
stressful events, depression, and cognitive impairment. Folic acid has been reported to …
stressful events, depression, and cognitive impairment. Folic acid has been reported to …
Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice
EH Taniguti, YS Ferreira, IJV Stupp… - Physiology & …, 2018 - Elsevier
Accumulating evidence indicates an interaction between inflammation and depression since
increased levels of pro-inflammatory cytokines are associated with depression-related …
increased levels of pro-inflammatory cytokines are associated with depression-related …
Folic acid ameliorates synaptic impairment following cerebral ischemia/reperfusion injury via inhibiting excessive activation of NMDA receptors
X Liang, L Shi, M Wang, L Zhang, Z Gong, S Luo… - The Journal of …, 2023 - Elsevier
Folic acid, a water-soluble B-vitamin, has been demonstrated to decrease the risk of first
stroke and improve its poor prognosis. However, the molecular mechanisms responsible for …
stroke and improve its poor prognosis. However, the molecular mechanisms responsible for …
Folic acid prevents depressive-like behavior induced by chronic corticosterone treatment in mice
PB Rosa, CM Ribeiro, LEB Bettio, A Colla… - Pharmacology …, 2014 - Elsevier
The objective of this study was to investigate the effects of folic acid on depressive-like
behavior induced by chronic administration of corticosterone in mice. Corticosterone (20 …
behavior induced by chronic administration of corticosterone in mice. Corticosterone (20 …
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide–cGMP and PI3K/mTOR pathways
Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …
glutamatergic transmission and neuroprotection. The present study evaluated the …