Biofilms as promoters of bacterial antibiotic resistance and tolerance

C Uruén, G Chopo-Escuin, J Tommassen… - Antibiotics, 2020 - mdpi.com
Multidrug resistant bacteria are a global threat for human and animal health. However, they
are only part of the problem of antibiotic failure. Another bacterial strategy that contributes to …

Dysbiosis of the gut and lung microbiome has a role in asthma

K Hufnagl, I Pali-Schöll, F Roth-Walter… - Seminars in …, 2020 - Springer
Worldwide 300 million children and adults are affected by asthma. The development of
asthma is influenced by environmental and other exogenous factors synergizing with …

Bacterial exo-polysaccharides in biofilms: role in antimicrobial resistance and treatments

S Singh, S Datta, KB Narayanan… - Journal of Genetic …, 2021 - Springer
Background Bacterial biofilms are aggregation or collection of different bacterial cells which
are covered by self-produced extracellular matrix and are attached to a substratum …

Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria

CW Hall, TF Mah - FEMS microbiology reviews, 2017 - academic.oup.com
Biofilms are surface-attached groups of microbial cells encased in an extracellular matrix
that are significantly less susceptible to antimicrobial agents than non-adherent, planktonic …

[HTML][HTML] Bacterial exopolysaccharides as emerging bioactive macromolecules: from fundamentals to applications

N Kaur, P Dey - Research in microbiology, 2023 - Elsevier
Microbial exopolysaccharides (EPS) are extracellular carbohydrate polymers forming
capsules or slimy coating around the cells. EPS can be secreted by various bacterial genera …

“It takes a village”: mechanisms underlying antimicrobial recalcitrance of polymicrobial biofilms

G Orazi, GA O'Toole - Journal of Bacteriology, 2019 - Am Soc Microbiol
Chronic infections are frequently caused by polymicrobial biofilms. Importantly, these
infections are often difficult to treat effectively in part due to the recalcitrance of biofilms to …

Better together: engineering and application of microbial symbioses

SG Hays, WG Patrick, M Ziesack, N Oxman… - Current opinion in …, 2015 - Elsevier
Highlights•Microbial communities are naturally abundant.•Natural symbioses exhibit
increased robustness and metabolic capabilities.•Technological advances in environmental …

[HTML][HTML] Polymicrobial infections and biofilms: clinical significance and eradication strategies

VT Anju, S Busi, M Imchen, R Kumavath, MS Mohan… - Antibiotics, 2022 - mdpi.com
Biofilms are population of cells growing in a coordinated manner and exhibiting resistance
towards hostile environments. The infections associated with biofilms are difficult to control …

Airway microbiota dynamics uncover a critical window for interplay of pathogenic bacteria and allergy in childhood respiratory disease

SM Teo, HHF Tang, D Mok, LM Judd, SC Watts… - Cell host & …, 2018 - cell.com
Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis
of persistent wheezing disease in children. In this study, the occurrence of acute respiratory …

Formation, development, and cross-species interactions in biofilms

A Luo, F Wang, D Sun, X Liu, B Xin - Frontiers in Microbiology, 2022 - frontiersin.org
Biofilms, which are essential vectors of bacterial survival, protect microbes from antibiotics
and host immune attack and are one of the leading causes that maintain drug-resistant …