The current treatment of clinical orthopedic diseases is not very ideal. For example, after
treatment, it is easy to be accompanied by large-scale osteochondral defects, blood vessels …

The hallmark of enthesis architecture is the 3D compositional and structural gradient
encompassing four tissue zones–tendon/ligament, uncalcified fibrocartilage, calcified …

It is well documented that fragility fractures represent an enormous health, economic and
psycho-social burden, leading to severe pain, loss of mobility, and even death. While clinical …

Nonunion and large bone defects caused by trauma, tumor resection, and other bone
diseases pose great challenges for clinical treatment. In this work, we fabricated a …

Bone is a highly hierarchical complex structure that consists of organic and mineral
components represented by collagen molecules (CM) and hydroxyapatite crystals (HAC) …

Understanding the properties of bone is of both fundamental and clinical relevance. The
basis of bone's quality and mechanical resilience lies in its nanoscale building blocks (ie …

Biomineral crystal growth within extracellular fiber assemblies is regulated broadly and at
fine scales by proteins and small molecules. While small-molecule and protein inhibitors …

Bone is a highly hierarchical complex structure that consists of organic and mineral
components represented by collagen molecules (CM) and hydroxyapatite crystals (HAC) …

Background: Diabetes mellitus and osteoporosis are two common medical disorders that are
becoming more common as the population ages. T2DM patients have a higher fracture …