Big data approaches to decomposing heterogeneity across the autism spectrum

MV Lombardo, MC Lai, S Baron-Cohen - Molecular psychiatry, 2019 - nature.com
Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …

Genetic contributions to autism spectrum disorder

A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …

Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders

J Seidlitz, A Nadig, S Liu, RAI Bethlehem… - Nature …, 2020 - nature.com
Neurodevelopmental disorders have a heritable component and are associated with region
specific alterations in brain anatomy. However, it is unclear how genetic risks for …

Prenatal origins of ASD: the when, what, and how of ASD development

E Courchesne, VH Gazestani, NE Lewis - Trends in neurosciences, 2020 - cell.com
Autism spectrum disorder (ASD) is a largely heritable, multistage prenatal disorder that
impacts a child's ability to perceive and react to social information. Most ASD risk genes are …

Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

S Trakoshis, P Martínez-Cañada, F Rocchi, C Canella… - elife, 2020 - elifesciences.org
Excitation-inhibition (E: I) imbalance is theorized as an important pathophysiological
mechanism in autism. Autism affects males more frequently than females and sex-related …

Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism

B Park, SJ Hong, SL Valk, C Paquola… - Nature …, 2021 - nature.com
The pathophysiology of autism has been suggested to involve a combination of both
macroscale connectome miswiring and microcircuit anomalies. Here, we combine …

Differences in regional brain structure in toddlers with autism are related to future language outcomes

K Duan, L Eyler, K Pierce, MV Lombardo… - Nature …, 2024 - nature.com
Abstract Language and social symptoms improve with age in some autistic toddlers, but not
in others, and such outcome differences are not clearly predictable from clinical scores …

[HTML][HTML] Get SET early to identify and treatment refer autism spectrum disorder at 1 year and discover factors that influence early diagnosis

K Pierce, V Gazestani, E Bacon, E Courchesne… - The Journal of …, 2021 - Elsevier
Objectives To examine the impact of a new approach, Get SET Early, on the rates of early
autism spectrum disorder (ASD) detection and factors that influence the screen-evaluate …

A perturbed gene network containing PI3K–AKT, RAS–ERK and WNT–β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity

VH Gazestani, T Pramparo, S Nalabolu… - Nature …, 2019 - nature.com
Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms
through which they contribute to ASD pathophysiology remain elusive. Here we analyzed …

Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder

X Guo, G Zhai, J Liu, Y Cao, X Zhang, D Cui, L Gao - Molecular Autism, 2022 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with
considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD …