Big data approaches to decomposing heterogeneity across the autism spectrum
Autism is a diagnostic label based on behavior. While the diagnostic criteria attempt to
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …
maximize clinical consensus, it also masks a wide degree of heterogeneity between and …
Genetic contributions to autism spectrum disorder
A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …
conditions characterized by early childhood-onset impairments in communication and social …
Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
Neurodevelopmental disorders have a heritable component and are associated with region
specific alterations in brain anatomy. However, it is unclear how genetic risks for …
specific alterations in brain anatomy. However, it is unclear how genetic risks for …
Prenatal origins of ASD: the when, what, and how of ASD development
Autism spectrum disorder (ASD) is a largely heritable, multistage prenatal disorder that
impacts a child's ability to perceive and react to social information. Most ASD risk genes are …
impacts a child's ability to perceive and react to social information. Most ASD risk genes are …
Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women
Excitation-inhibition (E: I) imbalance is theorized as an important pathophysiological
mechanism in autism. Autism affects males more frequently than females and sex-related …
mechanism in autism. Autism affects males more frequently than females and sex-related …
Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism
The pathophysiology of autism has been suggested to involve a combination of both
macroscale connectome miswiring and microcircuit anomalies. Here, we combine …
macroscale connectome miswiring and microcircuit anomalies. Here, we combine …
Differences in regional brain structure in toddlers with autism are related to future language outcomes
Abstract Language and social symptoms improve with age in some autistic toddlers, but not
in others, and such outcome differences are not clearly predictable from clinical scores …
in others, and such outcome differences are not clearly predictable from clinical scores …
[HTML][HTML] Get SET early to identify and treatment refer autism spectrum disorder at 1 year and discover factors that influence early diagnosis
Objectives To examine the impact of a new approach, Get SET Early, on the rates of early
autism spectrum disorder (ASD) detection and factors that influence the screen-evaluate …
autism spectrum disorder (ASD) detection and factors that influence the screen-evaluate …
A perturbed gene network containing PI3K–AKT, RAS–ERK and WNT–β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity
VH Gazestani, T Pramparo, S Nalabolu… - Nature …, 2019 - nature.com
Hundreds of genes are implicated in autism spectrum disorder (ASD), but the mechanisms
through which they contribute to ASD pathophysiology remain elusive. Here we analyzed …
through which they contribute to ASD pathophysiology remain elusive. Here we analyzed …
Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder
X Guo, G Zhai, J Liu, Y Cao, X Zhang, D Cui, L Gao - Molecular Autism, 2022 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with
considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD …
considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD …