Cognition in multiple sclerosis: State of the field and priorities for the future

JF Sumowski, R Benedict, C Enzinger, M Filippi… - Neurology, 2018 - AAN Enterprises
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis
(MS), especially deficits in episodic memory and processing speed. The field aims to (1) …

Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis

MA Rocca, MP Amato, N De Stefano… - The Lancet …, 2015 - thelancet.com
In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

The pathogenesis of tuberculous meningitis

AG Davis, UK Rohlwink, A Proust… - Journal of leukocyte …, 2019 - academic.oup.com
Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

O Ciccarelli, F Barkhof, B Bodini, N De Stefano… - The Lancet …, 2014 - thelancet.com
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …

Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis

G Mandolesi, A Gentile, A Musella… - Nature Reviews …, 2015 - nature.com
Multiple sclerosis (MS) has long been regarded as a chronic inflammatory disease of the
white matter that leads to demyelination and eventually to neurodegeneration. In the past …

Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis

N Cawley, BS Solanky, N Muhlert, C Tur, RAE Edden… - Brain, 2015 - academic.oup.com
Neurodegeneration is thought to be the major cause of ongoing, irreversible disability in
progressive stages of multiple sclerosis. Gamma-aminobutyric acid is the principle inhibitory …

[HTML][HTML] Thalamic injury and cognition in multiple sclerosis

M Amin, D Ontaneda - Frontiers in Neurology, 2021 - frontiersin.org
Multiple sclerosis (MS) produces demyelination and degeneration in both gray and white
matter. Both cortical and deep gray matter injury is observed during the course of MS …

Correspondence among gray matter atrophy and atlas-based neurotransmitter maps is clinically relevant in multiple sclerosis

A Fiore, P Preziosa, N Tedone, M Margoni… - Molecular …, 2023 - nature.com
In multiple sclerosis (MS), gray matter (GM) atrophy progresses in a non-random manner,
possibly in regions with a high distribution of specific neurotransmitters involved in several …

Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities

R Macrez, PK Stys, D Vivien, SA Lipton… - The Lancet …, 2016 - thelancet.com
Research advances support the idea that excessive activation of the glutamatergic pathway
plays an important part in the pathophysiology of multiple sclerosis. Beyond the well …