Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic
pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia …

This comprehensive State of the Art review summarizes the current published knowledge
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …

Background Airway oedema (swelling) and mucus plugging are the principal pathological
features in infants with acute viral bronchiolitis. Nebulised hypertonic saline solution (≥ 3%) …

Background Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-
term trials, improves lung function in people with cystic fibrosis. We tested the safety and …

Conclusion This is the first extensive systematic literature review undertaken of the existing
evidence surrounding comprehensive physiotherapy management of the spontaneously …

Abbreviations: ADA Americans with Disabilities Act; BMD bone mineral density; BMI body
mass index; CBAVD congenital bilateral absence of the vas deferens; CF cystic fibrosis; CFF …

Background Abnormal homeostasis of the volume of airway surface liquid in patients with
cystic fibrosis is thought to produce defects in mucus clearance and airway defense …

The survival of patients with cystic fibrosis (CF) continues to improve. The discovery and
cloning of the CFTR gene more than 21 years ago led to the identification of the structure …

Although there has been impressive progress in the elucidation of the genetic and molecular
basis of cystic fibrosis (CF), the pathogenesis of CF lung disease remains obscure. The …