On modeling

DS Novikov, VG Kiselev… - Magnetic resonance in …, 2018 - Wiley Online Library
Mapping tissue microstructure with MRI holds great promise as a noninvasive window into
tissue organization at the cellular level. Having originated within the realm of diffusion NMR …

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

DS Novikov, E Fieremans, SN Jespersen… - NMR in …, 2019 - Wiley Online Library
We review, systematize and discuss models of diffusion in neuronal tissue, by putting them
into an overarching physical context of coarse‐graining over an increasing diffusion length …

Noninvasive quantification of axon radii using diffusion MRI

J Veraart, D Nunes, U Rudrapatna, E Fieremans… - elife, 2020 - elifesciences.org
Axon caliber plays a crucial role in determining conduction velocity and, consequently, in the
timing and synchronization of neural activation. Noninvasive measurement of axon radii …

[HTML][HTML] Neurite Exchange Imaging (NEXI): A minimal model of diffusion in gray matter with inter-compartment water exchange

IO Jelescu, A de Skowronski, F Geffroy, M Palombo… - NeuroImage, 2022 - Elsevier
Biophysical models of diffusion in white matter have been center-stage over the past two
decades and are essentially based on what is now commonly referred to as the “Standard …

[HTML][HTML] Challenges for biophysical modeling of microstructure

IO Jelescu, M Palombo, F Bagnato… - Journal of Neuroscience …, 2020 - Elsevier
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Rotationally-invariant mapping of scalar and orientational metrics of neuronal microstructure with diffusion MRI

DS Novikov, J Veraart, IO Jelescu, E Fieremans - NeuroImage, 2018 - Elsevier
We develop a general analytical and numerical framework for estimating intra-and extra-
neurite water fractions and diffusion coefficients, as well as neurite orientational dispersion …

Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI

DK Jones, DC Alexander, R Bowtell, M Cercignani… - NeuroImage, 2018 - Elsevier
The key component of a microstructural diffusion MRI 'super-scanner'is a dedicated high-
strength gradient system that enables stronger diffusion weightings per unit time compared …

On the scaling behavior of water diffusion in human brain white matter

J Veraart, E Fieremans, DS Novikov - NeuroImage, 2019 - Elsevier
Abstract Development of therapies for neurological disorders depends on our ability to non-
invasively diagnose and monitor the progression of underlying pathologies at the cellular …

[HTML][HTML] Diffusion time dependence, power-law scaling, and exchange in gray matter

JL Olesen, L Østergaard, N Shemesh, SN Jespersen - NeuroImage, 2022 - Elsevier
Characterizing neural tissue microstructure is a critical goal for future neuroimaging.
Diffusion MRI (dMRI) provides contrasts that reflect diffusing spins' interactions with myriad …

Towards unconstrained compartment modeling in white matter using diffusion‐relaxation MRI with tensor‐valued diffusion encoding

B Lampinen, F Szczepankiewicz… - Magnetic resonance …, 2020 - Wiley Online Library
Purpose To optimize diffusion‐relaxation MRI with tensor‐valued diffusion encoding for
precise estimation of compartment‐specific fractions, diffusivities, and T2 values within a two …