Genetic, environmental and lifestyle determinants of accelerated telomere attrition as contributors to risk and severity of multiple sclerosis
Telomeres are protective structures at the ends of linear chromosomes. Shortened telomere
lengths (TL) are an indicator of premature biological aging and have been associated with a …
lengths (TL) are an indicator of premature biological aging and have been associated with a …
The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunities
A Afrasiabi, C Ahlenstiel… - Clinical & …, 2023 - Wiley Online Library
Multiple sclerosis (MS) is a chronic neurodegenerative autoimmune disease, characterised
by the demyelination of neurons in the central nervous system. Whilst it is unclear what …
by the demyelination of neurons in the central nervous system. Whilst it is unclear what …
BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Abstract Interleukin-17 (IL-17)-producing helper T (TH17) cells are heterogenous and
consist of nonpathogenic TH17 (npTH17) cells that contribute to tissue homeostasis and …
consist of nonpathogenic TH17 (npTH17) cells that contribute to tissue homeostasis and …
Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes
Genome-wide association studies (GWAS) successfully identified multiple sclerosis (MS)
susceptibility variants. Despite this notable progress, understanding the biological context of …
susceptibility variants. Despite this notable progress, understanding the biological context of …
Multi-omic profiling reveals early immunological indicators for identifying COVID-19 Progressors
KA Drake, D Talantov, GJ Tong, JT Lin, S Verheijden… - Clinical …, 2023 - Elsevier
We sought to better understand the immune response during the immediate post-diagnosis
phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by identifying …
phase of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by identifying …
Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy
Background Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenerative
disease that leads to irreversible damage to the brain and spinal cord. The goal of so-called" …
disease that leads to irreversible damage to the brain and spinal cord. The goal of so-called" …
Implication of genetic variants in primary microRNA processing sites in the risk of multiple sclerosis
Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system with a well-established genetic contribution to susceptibility. Over 200 genetic …
system with a well-established genetic contribution to susceptibility. Over 200 genetic …
The chromatin landscape of Th17 cells reveals mechanisms of diversification of regulatory and pro-inflammatory states
Th17 cells are a heterogenous cell population consisting of non-pathogenic Th17 cells
(npTh17) that contribute to tissue homeostasis and pathogenic Th17 cells (pTh17) that are …
(npTh17) that contribute to tissue homeostasis and pathogenic Th17 cells (pTh17) that are …
Multiple Sclerosis Onset before and after COVID-19 Vaccination: Can HLA Haplotype Be Determinant?
A Bianco, G Di Sante, F Colò, V De Arcangelis… - International Journal of …, 2024 - mdpi.com
A few cases of multiple sclerosis (MS) onset after COVID-19 vaccination have been
reported, although the evidence is insufficient to establish causality. The aim of this study is …
reported, although the evidence is insufficient to establish causality. The aim of this study is …
[HTML][HTML] Differential gene expression in B cells and T helper cells following high-dose glucocorticoid therapy for multiple sclerosis relapse
Background Despite remarkable advances in the therapy of multiple sclerosis (MS), patients
with MS may still experience relapses. High-dose short-term methylprednisolone (MP) …
with MS may still experience relapses. High-dose short-term methylprednisolone (MP) …