Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

Antibiotic discovery and resistance: the chase and the race

K Iskandar, J Murugaiyan, D Hammoudi Halat… - Antibiotics, 2022 - mdpi.com
The history of antimicrobial resistance (AMR) evolution and the diversity of the
environmental resistome indicate that AMR is an ancient natural phenomenon. Acquired …

Nanobiotics against antimicrobial resistance: harnessing the power of nanoscale materials and technologies

N Chakraborty, D Jha, I Roy, P Kumar… - Journal of …, 2022 - Springer
Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of
“post-antibiotic era”. It is anticipated that current SARS-CoV2 pandemic would worsen the …

Back to Nature: Medicinal plants as promising sources for antibacterial drugs in the post-antibiotic era

EM Abdallah, BY Alhatlani, R de Paula Menezes… - Plants, 2023 - mdpi.com
Undoubtedly, the advent of antibiotics in the 19th century had a substantial impact,
increasing human life expectancy. However, a multitude of scientific investigations now …

Design and synthesis of novel antimicrobial agents

Z Breijyeh, R Karaman - Antibiotics, 2023 - mdpi.com
The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal

A Tarín-Pelló, B Suay-García… - Expert Review of Anti …, 2022 - Taylor & Francis
Introduction Antibiotic resistance is one of the biggest public health threats worldwide.
Currently, antibiotic-resistant bacteria kill 700,000 people every year. These data represent …

Wastewater treatment plants, an “escape gate” for ESCAPE pathogens

LG Marutescu, M Popa, I Gheorghe-Barbu… - Frontiers in …, 2023 - frontiersin.org
Antibiotics are an essential tool of modern medicine, contributing to significantly decreasing
mortality and morbidity rates from infectious diseases. However, persistent misuse of these …

Heavy-Metal Trojan Horse: Enterobactin-Directed Delivery of Platinum(IV) Prodrugs to Escherichia coli

C Guo, EM Nolan - Journal of the American Chemical Society, 2022 - ACS Publications
The global crisis of untreatable microbial infections necessitates the design of new
antibiotics. Drug repurposing is a promising strategy for expanding the antibiotic repertoire …

Antibiotic adjuvants: Synergistic tool to combat multi-drug resistant pathogens

V Kumar, N Yasmeen, A Pandey… - Frontiers in Cellular …, 2023 - frontiersin.org
The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of
infectious disease treatment. To overcome this problem, novel strategies are being explored …

Drug repurposing to overcome microbial resistance

J Jampilek - Drug Discovery Today, 2022 - Elsevier
Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …