The Wnt/β-catenin signaling pathway is a highly conserved pathway that is involved in cell
development, proliferation, differentiation, apoptosis and autophagy. Among these …

Hepatocellular carcinoma (HCC) exerts huge effects on the health burden of the world
because of its high mortality and poor prognosis. HCC is often clinically detected late in …

Background Accumulating evidence shows that N6-methyladenine (m 6 A) modulators
contribute to the etiology and progression of colorectal cancer (CRC). However, the exact …

The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is overexpressed in several tumor
entities, promotes tumorigenesis and tumor progression, and has been suggested to worsen …

Wnt/β-catenin is a developmental signaling pathway that plays a crucial role in driving
kidney fibrosis after injury. Activation of β-catenin is presumed to be regulated through the …

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy
mainly due to its extensive metastasis. Cancer-type organic anion transporting polypeptide …

Liver cancer is the fifth most widespread in the world, with a high fatality rate and poor
prognosis. However, surgicalresction, thermal/radiofrequencyablation, chemo …

Abstract p62 is an important multifunctional adaptor protein participating in autophagy and
many other activities. Many studies have revealed that p62 is highly expressed in multiple …

Malignant tumors remain the health problem of highest concern among people worldwide
due to its high mortality and recurrence. Lung, gastric, liver, colon, and breast cancers are …

Tumors refractory to conventional therapy belong to specific subpopulations of cancer cells,
which have acquired a higher number of mutations/epigenetic changes than the majority of …