Fibrosis and cancer: A strained relationship
Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …
Idiopathic pulmonary fibrosis
FJ Martinez, HR Collard, A Pardo, G Raghu… - Nature reviews Disease …, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It …
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
DH Peng, BL Rodriguez, L Diao, L Chen… - Nature …, 2020 - nature.com
Tumor extracellular matrix has been associated with drug resistance and immune
suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung …
suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung …
Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets
B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …
The fibrotic tumor stroma
M Yamauchi, TH Barker, DL Gibbons… - The Journal of clinical …, 2018 - Am Soc Clin Investig
Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-
associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical …
associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical …
Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development
AV Samarelli, V Masciale, B Aramini, GP Coló… - International journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …
disease (ILD) of unknown aetiology, with a median survival of 2–4 years from the time of …
Molecular mechanisms of pulmonary fibrogenesis and its progression to lung cancer: a review
T Kinoshita, T Goto - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …
fibrosing interstitial pneumonia of unknown cause, occurring primarily in older adults, and …
Understanding the role of dopamine in cancer: past, present and future
Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …
classically characterized according to its role in the central nervous system as a …
The role of the mammalian target of rapamycin (mTOR) in pulmonary fibrosis
J Lawrence, R Nho - International journal of molecular sciences, 2018 - mdpi.com
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …
Inflammation, fibrosis and cancer: mechanisms, therapeutic options and challenges
Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …
term inflammation could be a protective response while uncontrolled inflammation sustains …