NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Emerging role of aging in the progression of NAFLD to HCC

Y He, Y Su, C Duan, S Wang, W He, Y Zhang… - Ageing Research …, 2023 - Elsevier
With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

Reprogramming of hepatic metabolism and microenvironment in nonalcoholic steatohepatitis

L Rui, JD Lin - Annual review of nutrition, 2022 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD), a spectrum of metabolic liver disease associated
with obesity, ranges from relatively benign hepatic steatosis to nonalcoholic steatohepatitis …

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

M Juárez‐Fernández, N Goikoetxea‐Usandizaga… - Hepatology, 2023 - journals.lww.com
Abstract Background and Aims: Recent studies suggest that mitochondrial dysfunction
promotes progression to NASH by aggravating the gut-liver status. However, the underlying …

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

RW Dellinger, HE Holmes, T Hu‐Seliger, RW Butt… - Hepatology, 2023 - journals.lww.com
Nicotinamide riboside and pterostilbene reduces markers of h... : Hepatology Nicotinamide
riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind …

Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice

Q Escalante-Covarrubias, L Mendoza-Viveros… - Nature …, 2023 - nature.com
The circadian clock is an endogenous time-tracking system that anticipates daily
environmental changes. Misalignment of the clock can cause obesity, which is accompanied …

Synthesis, Optimization, and Structure–Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs)

Z Shen, K Ratia, I Krider… - Journal of Medicinal …, 2023 - ACS Publications
Depletion of nicotinamide adenine dinucleotide (NAD+) is associated with aging and
disease, spurring the study of dietary supplements to replenish NAD+. The catabolism of …

Гепатопротекторы

СВ Оковитый, ВА Приходько, НН Безбородкина… - 2022 - elibrary.ru
В настоящем издании проанализированы и систематизированы сведения по
клиническому применению лекарственных средств, для которых гепатотропное …

Nad+ Precursors and intestinal inflammation: therapeutic insights involving gut microbiota

J Niño-Narvión, MI Rojo-López, P Martinez-Santos… - Nutrients, 2023 - mdpi.com
The oxidized form of nicotinamide adenine dinucleotide (NAD+) is a critical metabolite for
living cells. NAD+ may act either as a cofactor for many cellular reactions as well as a …

[HTML][HTML] Mitochondrial quality control: its role in metabolic dysfunction-associated steatotic liver disease (MASLD)

S Shin, J Kim, JY Lee, J Kim, CM Oh - Journal of Obesity & …, 2023 - ncbi.nlm.nih.gov
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-
alcoholic fatty liver disease, is characterized by hepatic steatosis and metabolic dysfunction …