Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

The non-essential amino acid serine supports several metabolic processes that are crucial
for the growth and survival of proliferating cells, including protein, amino acid and …

Serine/glycine biosynthesis and one-carbon metabolism are crucial in sustaining cancer cell
survival and rapid proliferation, and of high clinical relevance. Excessive activation of …

While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …

Serine and glycine are biosynthetically linked, and together provide the essential precursors
for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth …

Energy metabolism is significantly reprogrammed in many human cancers, and these
alterations confer many advantages to cancer cells, including the promotion of biosynthesis …

During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …

Cancer cells are known to undergo metabolic reprogramming to sustain survival and rapid
proliferation, however, it remains to be fully elucidated how oncogenic lesions coordinate …