High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations

DG Delafield, G Lu, CJ Kaminsky, L Li - TrAC Trends in Analytical …, 2022 - Elsevier
Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

Advanced analytical and informatic strategies for metabolite annotation in untargeted metabolomics

Y Cai, Z Zhou, ZJ Zhu - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Liquid chromatography–mass spectrometry (LC–MS)-based untargeted metabolomics is
constantly challenged by large-scale and unambiguous metabolite annotation in complex …

[HTML][HTML] Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain

T Li, Y Yin, Z Zhou, J Qiu, W Liu, X Zhang, K He… - Nature …, 2021 - nature.com
Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging
brain and aging-dependent disorders such as neurodegenerative diseases. There is an …

Ion mobility mass spectrometry for the separation and characterization of small molecules

L Liu, Z Wang, Q Zhang, Y Mei, L Li, H Liu… - Analytical …, 2023 - ACS Publications
Small molecules with molecular weights less than 1500 Da represented by natural
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …

A preprocessing tool for enhanced ion mobility–mass spectrometry-based omics workflows

A Bilbao, BC Gibbons, SM Stow, JE Kyle… - Journal of proteome …, 2021 - ACS Publications
The ability to improve the data quality of ion mobility–mass spectrometry (IM-MS)
measurements is of great importance for enabling modular and efficient computational …

Collision cross section measurement and prediction methods in omics

KY Kartowikromo, OE Olajide… - Journal of mass …, 2023 - Wiley Online Library
Omics studies such as metabolomics, lipidomics, and proteomics have become important for
understanding the mechanisms in living organisms. However, the compounds detected are …

[HTML][HTML] Software and computational tools for LC-MS-based epilipidomics: Challenges and solutions

T Damiani, S Bonciarelli, GG Thallinger… - Analytical …, 2023 - ACS Publications
Lipids play a crucial role in cellular structure and functions, including cell signaling,
membrane plasticity, and trafficking. Alterations of the lipid composition in cells, tissues, or …

Trapped ion mobility spectrometry-mass spectrometry improves the coverage and accuracy of four-dimensional untargeted lipidomics

X Chen, Y Yin, M Luo, Z Zhou, Y Cai, ZJ Zhu - Analytica chimica acta, 2022 - Elsevier
Lipids play vital roles in many physiological and pathological processes in living organisms.
Due to the high structural diversity and the numerous isomers and isobars of lipids, high …

Spatial lipidomics of eight edible nuts by desorption electrospray ionization with ion mobility mass spectrometry imaging

J Hou, Z Zhang, L Zhang, W Wu, Y Huang, Z Jia… - Food Chemistry, 2022 - Elsevier
Nuts have long been known for their health benefits which are mainly contributed by their
lipid components. However, the spatial distribution of lipids in nuts has not been firmly …

[HTML][HTML] Investigation of the lipidomic profile of royal jelly from different botanical origins using UHPLC-IM-Q-TOF-MS and GC-MS

S Yan, X Wang, M Sun, W Wang, L Wu, X Xue - LWT, 2022 - Elsevier
Royal jelly (RJ) is a popular nutraceutical with myriad biological functions. The lipid
composition of RJ is unlike most plant and animal materials, giving RJ unique health …