Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune
inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's …

The gastrointestinal tract harbors numerous commensal bacteria, referred to as the
microbiota, that benefit host health by digesting dietary components and eliminating …

B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …

Pectins are dietary fibers with different structural characteristics. Specific pectin structures
can influence the gastrointestinal immune barrier by directly interacting with immune cells or …

Various immune mechanisms are deployed in the mucosa to confront the immense diversity
of resident bacteria. A substantial fraction of the commensal microbiota is coated with …

The intestine represents the largest compartment of the immune system. It is continually
exposed to antigens and immunomodulatory agents from the diet and the commensal …

The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated α-
synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we …

Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial
strains that drive gut IgA production remain largely unknown. Here, we assessed the IgA …

Secondary lymphoid tissues share the important function of bringing together antigens and
rare antigen‐specific lymphocytes to foster induction of adaptive immune responses. Peyer's …

Leukocyte trafficking to the small and large intestines is tightly controlled to maintain
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …