The homeobox (HOX) genes are a highly conserved family of homeodomain-containing
transcription factors that specify cell identity in early development and, subsequently, in a …

Further incorporation of genomic and molecular data in pediatric AML will allow for
additional refinements in risk stratification to enable the tailoring of treatment intensity. These …

Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily
balanced translocations and inversions, are associated with a wide array of hematopoietic …

Gene expression analyses, gene targeting experiments and retroviral overexpression
studies in the murine bone marrow transplantation model have provided strong correlative …

Abstract Myeloid cell leukemia-1 (MCL-1) is an essential survival factor for hematopoiesis. In
humans, hematopoietic stem cells (HSCs) express MCL-1 at the highest level in response to …

Quinoxalines are benzopyrazines containing benzene and pyrazine rings fused together. In
the recent past, quinoxalines have attracted Medicinal Chemists considerably for their …

The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …

Simple Summary Protein phosphorylation is a key regulatory mechanism that controls a
wide variety of cellular responses. This process is catalysed by the members of the protein …

NUP98/NSD1 has recently been reported in association with poor outcome in acute myeloid
leukemia (AML). Previous studies also observed a high overlap between NUP98/NSD1 and …

Overexpression of wild-type MN1 is a negative prognostic factor in patients with acute
myeloid leukemia (AML) with normal cytogenetics. We evaluated whether MN1 plays a …