Bacteria that colonize the human gastrointestinal tract are essential for good health. The gut
microbiota has a critical role in pulmonary immunity and host's defense against viral …

Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …

Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting
in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue …

The intestinal immune system is an important modulator of glucose homeostasis and obesity-
associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites …

Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

Alterations in cellular metabolism underpin macrophage activation, yet little is known
regarding how key immunological molecules regulate metabolic programs in macrophages …

Atherosclerosis is an inflammatory disease with break-down of homeostatic immune
regulation of vascular tissues. As a critical initiator of host immunity, dendritic cells (DCs) …

Mucosal-associated invariant T (MAIT) cells are innate-like T cells present at considerable
frequencies in human blood and barrier tissues, armed with an expanding array of effector …

Dietary proteins are taken up by intestinal dendritic cells (DCs), cleaved into peptides,
loaded to major histocompatibility complexes, and presented to T cells to generate an …

The lipid sensor oleoylethanolamide (OEA), an endogenous high-affinity agonist of
peroxisome proliferator-activated receptor-α (PPAR-α) secreted in the proximal intestine, is …