Purpose Vitiligo-like depigmentation in patients with melanoma may be associated with
more favorable clinical outcome. We conducted a systematic review of patients with stage III …

Malignant melanoma continues to present a significant public health problem as its
incidence is rising faster than that of any other cancer in the US. At current rates, 1 in 74 …

Objective To evaluate the signs, symptoms, and immune responses of patients with
melanoma-associated retinopathy (MAR) syndrome. Materials and Methods We reviewed …

Over the last few decades a wealth of evidence has been gathered on the potential role that
the immune system (IS) can play in the fight against cancer. Together with cell surface …

Unusual neuro-ophthalmologic symptoms and signs that go unexplained should warrant a
thorough investigation for paraneoplastic syndromes. Although these syndromes are rare …

Purpose: A reason that the immune system may fail to reject tumors is that T cells encounter
tumor antigen derived peptides on the surface of tumor cells in a tolerizing rather than …

Whole-cell tumor vaccines have been investigated for more than 20 years for their efficacy in
both preclinical models and in clinical trials in humans. There are clear advantages of whole …

Marrow stromal cells (MSCs) can be easily gene-modified and clonally expanded making
them ideal candidates for transgenic cell therapy. However, recent reports suggest that …

Modification of the tumor microenvironment with gene transfer techniques stimulates two
immune mechanisms that effectuate tumor destruction. One involves improved tumor …

Whole cell tumor vaccine (WCTV), as a potential treatment modality, elicits limited immune
responses because of the poor immunogenicity. To address this issue, researchers have …