[HTML][HTML] Effectiveness of prothrombin complex concentrate for the treatment of bleeding: a systematic review and metaanalysis

DP van den Brink, MR Wirtz, AS Neto, H Schöchl… - Journal of thrombosis …, 2020 - Elsevier
Prothrombin complex concentrate (PCC) is increasingly being used as a treatment for major
bleeding in patients who are not taking anticoagulants. The aim of this systematic review …

[HTML][HTML] Prothrombin complex concentrate for trauma induced coagulopathy: a systematic review and meta-analysis

TW Kao, YC Lee, HT Chang - Journal of acute medicine, 2021 - ncbi.nlm.nih.gov
Background Optimal management for trauma-induced coagulopathy (TIC) is a clinical
conundrum. In conjunction with the transfusion of fresh-frozen plasma (FFP), additional …

Four-factor prothrombin complex concentrate is associated with improved survival in trauma-related hemorrhage: a nationwide propensity-matched analysis

M Zeeshan, M Hamidi, AJ Feinstein… - Journal of Trauma …, 2019 - journals.lww.com
METHODS Two-year (2015–2016) analysis of the American College of Surgeons-Trauma
Quality Improvement Program database. All adult (age≥ 18 years) trauma patients who …

Failure to rescue after emergency general surgery in geriatric patients: does frailty matter?

M Khan, F Jehan, M Zeeshan, N Kulvatunyou… - journal of surgical …, 2019 - Elsevier
Background Failure to rescue (FTR) is considered as an index of quality of care provided by
a hospital. However, the role of frailty in FTR remains unclear. We hypothesized that the FTR …

The role of four-factor prothrombin complex concentrate in coagulopathy of trauma: a propensity matched analysis

F Jehan, H Aziz, T O'Keeffe, M Khan… - Journal of Trauma …, 2018 - journals.lww.com
BACKGROUND Coagulopathy is a common complication after severe trauma. The efficacy
of 4-factor prothrombin complex concentrate (4-PCC) as an adjunct to fresh frozen plasma …

Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses

I Hannadjas, A James, R Davenport, C Lindsay… - Critical Care, 2023 - Springer
Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major
hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for …

ICU management of trauma patients

SA Tisherman, DM Stein - Critical Care Medicine, 2018 - journals.lww.com
Objectives: To describe the current state of the art regarding management of the critically ill
trauma patient with an emphasis on initial management in the ICU. Data Sources and Study …

Activitybased costs of plasma transfusions in medical and surgical inpatients at a US hospital

A Shander, S Ozawa, A Hofmann - Vox sanguinis, 2016 - Wiley Online Library
Background and objectives Fresh frozen plasma (FFP) usage has significantly increased
over the last decade leading to elevated healthcare costs. Although FFP is used in several …

Contemporary management of major haemorrhage in critical care

CL Maier, K Brohi, N Curry, NP Juffermans… - Intensive care …, 2024 - Springer
Haemorrhagic shock is frequent in critical care settings and responsible for a high mortality
rate due to multiple organ dysfunction and coagulopathy. The management of critically ill …

Applying the cell-based coagulation model in the management of critical bleeding

KM Ho, W Pavey - Anaesthesia and intensive care, 2017 - journals.sagepub.com
The cell-based coagulation model was proposed 15 years ago, yet has not been applied
commonly in the management of critical bleeding. Nevertheless, this alternative model may …