Beyond horizontal gene transfer: the role of plasmids in bacterial evolution

J Rodríguez-Beltrán, J DelaFuente… - Nature Reviews …, 2021 - nature.com
Plasmids have a key role in bacterial ecology and evolution because they mobilize
accessory genes by horizontal gene transfer. However, recent studies have revealed that …

Replication mechanisms of circular ssDNA plant viruses and their potential implication in viral gene expression regulation

M Bonnamy, S Blanc, Y Michalakis - mbio, 2023 - Am Soc Microbiol
The replication of members of the two circular single-stranded DNA (ssDNA) virus families
Geminiviridae and Nanoviridae, the only ssDNA viruses infecting plants, is believed to be …

[HTML][HTML] Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria

R Maddamsetti, Y Yao, T Wang, J Gao… - Nature …, 2024 - nature.com
Horizontal gene transfer (HGT) and gene duplication are often considered as separate
mechanisms driving the evolution of new functions. However, the mobile genetic elements …

High-throughput functional variant screens via in vivo production of single-stranded DNA

MG Schubert, DB Goodman… - Proceedings of the …, 2021 - National Acad Sciences
Creating and characterizing individual genetic variants remains limited in scale, compared
to the tremendous variation both existing in nature and envisioned by genome engineers …

Gene amplification, laboratory evolution, and biosensor screening reveal MucK as a terephthalic acid transporter in Acinetobacter baylyi ADP1

I Pardo, RK Jha, RE Bermel, F Bratti, M Gaddis… - Metabolic …, 2020 - Elsevier
Microbial terephthalic acid (TPA) catabolic pathways are conserved among the few bacteria
known to turnover this xenobiotic aromatic compound. However, to date there are few …

Genomic insights into linezolid-resistant Enterococci revealed its evolutionary diversity and poxtA copy number heterogeneity

Q Wang, K Peng, Z Liu, Y Li, X Xiao, XD Du, R Li… - International Journal of …, 2023 - Elsevier
Objectives This study aimed to determine the molecular mechanisms of linezolid-resistant
enterococci (LRE) in swine slaughterhouses in China and apply the “One Health” …

[HTML][HTML] Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications

P Allard, F Papazotos, L Potvin-Trottier - Frontiers in Bioengineering …, 2022 - frontiersin.org
Cells are inherently dynamic, whether they are responding to environmental conditions or
simply at equilibrium, with biomolecules constantly being made and destroyed. Due to their …

[HTML][HTML] Biochar-derived dissolved organic matters influencing bacterium characteristics during biodegradation of sulfamethoxazole and chloramphenicol under …

F Yang, Y Xue, Y Gao, Q Zhu, C Wang, H Sun - Biochar, 2023 - Springer
The influence of biochar-released dissolved organic matter (BDOM) on the transcription of
gene (DEG) in Pseudomonas stutzeri and Shewanella putrefacien during sulfamethoxazole …

[HTML][HTML] Local genetic context shapes the function of a gene regulatory network

A Nagy-Staron, K Tomasek, C Caruso Carter… - Elife, 2021 - elifesciences.org
Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some
of these interactions such as those of transcription factors and promoters have been studied …

Engineering plasmid copy number heterogeneity for dynamic microbial adaptation

S Kumar, A Lezia, J Hasty - Nature Microbiology, 2024 - nature.com
Natural microbial populations exploit phenotypic heterogeneity for survival and adaptation.
However, in engineering biology, limiting the sources of variability is a major focus. Here we …