Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …

In order to achieve coordinated growth and patterning during development, cells must
communicate with one another, sending and receiving signals that regulate their activities …

Endocytosis marks the entry of internalized receptors into the complex network of endocytic
trafficking pathways. Endocytic vesicles are rapidly targeted to a distinct membrane-bound …

Two endosome populations involved in recycling of membranes and receptors to the plasma
membrane have been described, the early and the recycling endosome. However, this …

The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

Plants constantly adjust their repertoire of plasma membrane proteins that mediates
transduction of environmental and developmental signals as well as transport of ions …

Foreign particles and apoptotic bodies are eliminated from the body by phagocytic
leucocytes. The initial stage of the elimination process is the internalization of the particles …

Phosphoinositide 3-kinases (PI 3-Ks) 1 are a subfamily of lipid kinases that catalyze the
addition of a phosphate molecule specifically to the 3-position of the inositol ring of …

Melanosomes and premelanosomes are lysosome-related organelles with a unique
structure and cohort of resident proteins. We have positioned these organelles relative to …

Abstract SNAREs and Rab GTPases cooperate in vesicle transport through a mechanism
yet poorly understood. We now demonstrate that the Rab5 effectors EEA1 and Rabaptin …