Physiological and pathological roles of protein kinase A in the heart
Protein kinase A (PKA) is a central regulator of cardiac performance and morphology.
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …
Protein serine/threonine phosphatases: keys to unlocking regulators and substrates
DL Brautigan, S Shenolikar - Annual review of biochemistry, 2018 - annualreviews.org
Protein serine/threonine phosphatases (PPPs) are ancient enzymes, with distinct types
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …
conserved across eukaryotic evolution. PPPs are segregated into types primarily on the …
HINT1 (histidine triad nucleotide-binding protein 1) attenuates cardiac hypertrophy via suppressing HOXA5 (homeobox A5) expression
Y Zhang, Q Da, S Cao, K Yan, Z Shi, Q Miao, C Li… - Circulation, 2021 - Am Heart Assoc
Background: Cardiac hypertrophy is an important prepathology of, and will ultimately lead to,
heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain …
heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain …
Histone deacetylases in cardiovascular and metabolic diseases
Histone deacetylases (HDACs) regulate gene transcription by catalyzing the removal of
acetyl groups from key lysine residues in nucleosomal histones and via the recruitment of …
acetyl groups from key lysine residues in nucleosomal histones and via the recruitment of …
Regulation of histone deacetylase activities and functions by phosphorylation and its physiological relevance
S Bahl, E Seto - Cellular and Molecular Life Sciences, 2021 - Springer
Histone deacetylases (HDACs) are conserved enzymes that regulate many cellular
processes by catalyzing the removal of acetyl groups from lysine residues on histones and …
processes by catalyzing the removal of acetyl groups from lysine residues on histones and …
Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early …
Y Jiang, Y He, S Liu, G Li, D Chen, W Deng, P Li… - Elife, 2023 - elifesciences.org
Decidualization, denoting the transformation of endometrial stromal cells into specialized
decidual cells, is a prerequisite for normal embryo implantation and a successful pregnancy …
decidual cells, is a prerequisite for normal embryo implantation and a successful pregnancy …
CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes
KG Helmstadter, S Ljubojevic-Holzer, BM Wood… - Basic research in …, 2021 - Springer
Abstract Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription,
implicated in the development of heart failure. CaMKII-dependent phosphorylation drives …
implicated in the development of heart failure. CaMKII-dependent phosphorylation drives …
Cyclic AMP represses pathological MEF2 activation by myocyte-specific hypo-phosphorylation of HDAC5
T He, J Huang, L Chen, G Han, D Stanmore… - Journal of Molecular and …, 2020 - Elsevier
Abstract Class IIa histone deacetylases (HDACs) critically regulate cardiac function through
the repression of the activity of myocyte enhancer factor 2 (MEF2)-dependent gene …
the repression of the activity of myocyte enhancer factor 2 (MEF2)-dependent gene …
PP2A and cancer epigenetics: a therapeutic opportunity waiting to happen
SL Tinsley, BL Allen-Petersen - Nar Cancer, 2022 - academic.oup.com
The epigenetic state of chromatin is altered by regulators which influence gene expression
in response to environmental stimuli. While several post-translational modifications …
in response to environmental stimuli. While several post-translational modifications …
LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway
F Lv, L Xie, L Li, J Lin - Scientific Reports, 2024 - nature.com
Abstract Background: Histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5)
are two isoforms of class IIa HDACs, and LMK235 is an HDAC inhibitor with higher …
are two isoforms of class IIa HDACs, and LMK235 is an HDAC inhibitor with higher …