Paleoproteomics, the study of ancient proteins, is a rapidly growing field at the intersection of
molecular biology, paleontology, archaeology, paleoecology, and history. Paleoproteomics …

Over the past ten years, scientific and technological advances have established biocatalysis
as a practical and environmentally friendly alternative to traditional metallo-and …

Rational protein engineering requires a holistic understanding of protein function. Here, we
apply deep learning to unlabeled amino-acid sequences to distill the fundamental features …

De novo protein design for catalysis of any desired chemical reaction is a long-standing goal
in protein engineering because of the broad spectrum of technological, scientific and …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Research of a past decade and a half leaves no doubt that complete understanding of
protein functionality requires close consideration of the fact that many functional proteins do …

Computational protein design has a wide variety of applications. Despite its remarkable
success, designing a protein for a given structure and function is still a challenging task. On …

Directed evolution circumvents our profound ignorance of how a protein's sequence
encodes its function by using iterative rounds of random mutation and artificial selection to …

The abundant existence of proteins and regions that possess specific functions without
being uniquely folded into unique 3D structures has become accepted by a significant …

Monoclonal antibodies represent an attractive therapeutic tool as they are highly specific for
their targets, convey effector functions and enjoy robust manufacturing procedures …