The central nervous system accounts for only 2% of the whole body mass but contains
almost a quarter of the unesterified cholesterol present in the whole individual. This sterol is …

It is widely believed that HDL functions to transport cholesterol from peripheral cells to the
liver by reverse cholesterol transport, a pathway that may protect against atherosclerosis by …

Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid
homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to …

Heritable variation in complex traits is generally considered to be conferred by common
DNA sequence polymorphisms. We tested whether rare DNA sequence variants collectively …

HDLs protect against the development of atherosclerosis, but the underlying mechanisms
are poorly understood. HDL and its apolipoproteins can promote cholesterol efflux from …

Sterol regulatory element-binding protein 2 (SREBP-2) transcription factor has been
identified as a key protein in cholesterol metabolism through the transactivation of the LDL …

Because cholesterol is a precursor for the synthesis of steroid hormones, steroidogenic
tissues have evolved multiple pathways to ensure adequate supplies of cholesterol. These …

Harlequin ichthyosis (HI) is a devastating skin disorder with an unknown underlying cause.
Abnormal keratinocyte lamellar granules (LGs) are a hallmark of HI skin. ABCA12 is a …

ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the
central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein …

Cholesterol efflux occurs by different pathways, including transport mediated by specific
proteins. We determined the effect of enriching cells with free cholesterol (FC) on the release …