How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …

Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

During pre-implantation development, the mammalian embryo self-organizes into the
blastocyst, which consists of an epithelial layer encapsulating the inner-cell mass (ICM) …

The major and essential objective of pre-implantation development is to establish embryonic
and extra-embryonic cell fates. To address when and how this fundamental process is …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …

The cadherin-catenin adhesion complex is the key component of the intercellular adherens
junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial …

During mouse pre-implantation development, the formation of the blastocoel, a fluid-filled
lumen, breaks the radial symmetry of the blastocyst. The factors that control the formation …